Clinical analysis of intracranial hemorrhage in children with hemophilia / 中华实用儿科临床杂志

Objective To discuss the risk factors,clinical characteristics,treatment protocol and prognosis of intracranial hemorrhage (ICH) in children with hemophilia.Methods Twenty-four hemophilic children with ICH,which were registered in hospital between Jan.2005 and Dec.2012,were reviewed retrospectively.Results (1) Fifteen patients were hemophilia A and 9 patients were hemophilia B,all boys.The mean age of ICH was 1 year and 7 months old.The 70.8％ of patients were less than 3 years old,among whom hemophilia was diagnosed after ICH in more than 88.9％.The 87.5％ of patients had moderate or severe disease,and 37.5％ had head trauma before ICH.(2) The clinical symptoms were high cranial pressure,anemia,disturbance of consciousness,seizure,hemiplegia.(3) ICH position:cerebral hemorrhage with subarachnoid hemorrhage (SAH) in 7 patients,ventricular hemorrhage 2 patients,subdural hemorrhage with SAH in 10 patients,extradural hemorrhage 5 patients.(4)All patients were given blood coagulation factor replacement therapy,5 patients by operation.(5)Thirteen patients had not sequelae,9 patients had sequelae and 2 patients died.Conclusions The risk factors of ICH in hemophilic children include ages less than 3 years old,moderate or severe disease.Some patients have no predispositions.The clinical symptoms of patients are similar with normal children suffering from ICH.The keys of treatment are early diagnosis,early treatment and adequate course of treatment.Surgical operation could be in treatment after coagulation function gets corrected back to normal.

Clinical Application of Ultrasonography on Tethered Spinal Cord Syndrome / 实用儿科临床杂志

Objective To explore the clinical application of ultrasonography on tethered spinal cord syndrome (TCS).Methods Ultrasonic feature of 45 patients with TCS were analyzed retrospectively. Pre-and post-operative blood flow rates of cone were recorded by color doppler.Results Ultrasound was the same as computer tomography not only presented the image of anatomy and pathology of TCS,but also showed the lack of pulsatile motion of distal cord with TCS.Before the operation,blood flow rates of cone were( 0.047?0.012) m/s.After the operation,blood flow rates of cone were(0.158?0.029) m/s.There was significantly different(P